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Search Results for " pim1 in 1 "

11

Compounds

Cat No. Product Name Synonyms Targets
T5093 Pim1/AKK1-IN-1 LKB1/AAK1 dual inhibitor,MDK-2275 Pim , Hippo pathway
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
T12474 PIM1-IN-1 Pim
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity.
T10828 CK2/PIM1-IN-1 Others
CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1 (IC50s: 3.787 μM and 4.327 μM). It is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions.
T63071 CDK6/PIM1-IN-1
CDK6/PIM1-IN-1 is a balanced, potent, dual CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM) inhibitor. CDK6/PIM1-IN-1 showed inhibitory effect on CDK4 with IC50 value of 3.6 nM. CDK6/PIM1-IN-1 can significantly inhibit the prol...
T10827 CK2/ERK8-IN-1 TMCB Apoptosis , ERK , Casein Kinase , Pim , DYRK
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25...
T62188 PIM1-IN-6
PIM1-IN-6 (compound 5h) is a potent inhibitor of PIM-1 (IC50: 0.60 μM).PIM1-IN-6 has a high cytotoxic effect on HCT-116 and MCF-7 cells with IC50 values of 1.51 and 15.2 μM, respectively.
T63720 PIM1-IN-3
PIM1-IN-3 (Compound HL8) is a potent inhibitor of PIM1 that selectively inhibits the PIM-1 enzyme and effectively induces apoptosis in Colo320 cells.PIM1-IN-3 has shown research potential for cancer diseases.
T73247 PIM1-IN-4 Pim
PIM1-IN-4 (Compound 8) is a potent PIM1 inhibitor with significant inhibitory activity against five additional enzymes: SGK-1, PKA, CaMK-1, GSK3β, and MSK1, rendering it a potentially useful agent for cancer research [1]...
T61700 PIM1-IN-7
PIM1-IN-7 (compound 6c) is a powerful inhibitor of PIM-1, effectively suppressing its activity with an IC50 of 0.67 μM. This compound also exhibits significant cytotoxicity against HCT-116 and MCF-7 cells, as demonstrate...
T81740 Multi-kinase-IN-6 Trk receptor
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX ca...
T79456 FD1024 Pim
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demonstrates significant antiproliferative effects on several AML...
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